Morton's Neuroma most commonly occurs between which toes?

• A. Between the first and second toes
• B. Between the second and third toes
• C. Between the third and fourth toes
• D. Between the fourth and fifth toes

Answer: (C)

Morton's neuroma is caused by irritation and entrapment of the plantar digital nerve in the forefoot. It most commonly occurs in the space between the third and fourth toes because the nerve runs between the third and fourth metatarsal heads there, and this interdigital area bears a lot of repetitive pressure during walking and with tight, narrow footwear. The resulting irritation leads to thickening of the nerve and characteristic symptoms—burning or sharp pain in the ball of the foot and into the toes, often worse with shoe squeeze or forefoot loading. On exam, a Mulder sign (a click or pulsation felt when the space is squeezed) can be supportive. While other interdigital spaces can be affected, the third-to-fourth space is by far the most common site.